Cardiovascular biomarkers in diabetic nephropathy
نویسندگان
چکیده
منابع مشابه
Tubulointerstitial Biomarkers for Diabetic Nephropathy
Patients with diabetic nephropathy have a higher risk of mortality, mostly from cardiovascular complications. Standard biomarkers including serum creatinine, estimated glomerular filtration rate, and albuminuria are imprecise, do not directly measure renal tissue injury, and are relatively insensitive to small changes in renal function. Thus, availability of novel biomarkers that are sensitive,...
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AIM Three urinary biomarkers, kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and cystatin C, have been suggested as clinically relevant highly specific biomarkers of acute kidney tubular damage. Yet, the utility of these biomarkers in the prognostication of diabetic nephropathy has been less studied. Therefore, we aimed to investigate the longitudinal assoc...
متن کاملRisk Factors for Diabetic Nephropathy in Diabetic Patients
Aims: Diabetic nephropathy is one of the consequences of type 1 and type 2 diabetes and one of the main causes of End-Stage Renal Disease (ESRD) as well as an important risk factor for cardiovascular morbidity and death. The aim of this study was to identify the risk factors for diabetic nephropathy in diabetic patients. Instruments & Methods: In this cross-sectional descriptive study, 121 pat...
متن کاملMarkers of endothelial dysfunction and inflammation in type 1 diabetic patients with or without diabetic nephropathy followed for 10 years: association with mortality and decline of glomerular filtration rate.
OBJECTIVE We evaluated the association of biomarkers of endothelial dysfunction and inflammation with all-cause mortality and cardiovascular mortality and morbidity and decline in glomerular filtration rate (GFR) in type 1 diabetic patients. RESEARCH DESIGN AND METHODS We prospectively followed 199 type 1 diabetic patients with diabetic nephropathy and 192 patients with persistent normoalbumi...
متن کاملUrinary Markers of Glomerular Injury in Diabetic Nephropathy
Diabetic nephropathy, the leading cause of renal failure worldwide, affects approximately one-third of all people with diabetes. Microalbuminuria is considered the first sign and the best predictor of progression to renal failure and cardiovascular events. However, albuminuria has several limitations. Therefore, earlier, more sensitive and specific biomarkers with greater predictability are nee...
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